/* ============================================================
   BIOMARKER PAGE — LML Theme v2.2.6
   Scoped to .bm-* — biomarker-oriented UI
   ============================================================ */

/* ── BREADCRUMB ─────────────────────────────────────────── */
.bm-breadcrumb{background:#F8FAFC;border-bottom:1px solid #E2E8F0;padding:.625rem 0}
.bm-bc-inner{max-width:1200px;margin:0 auto;padding:0 1.5rem;display:flex;align-items:center;gap:.5rem;font-size:.8125rem;color:#64748B}
.bm-bc-inner a{color:#64748B;text-decoration:none}
.bm-bc-inner a:hover{color:#1a2636}
.bm-bc-inner span[aria-current]{color:#1a2636;font-weight:500}

/* ── HERO ────────────────────────────────────────────────── */
.bm-hero{background:linear-gradient(135deg,#0F172A 0%,#1E293B 60%,#1a2636 100%);padding:4rem 0 3.5rem;position:relative;overflow:hidden}
.bm-hero::before{content:'';position:absolute;inset:0;background:radial-gradient(ellipse 60% 80% at 70% 50%,color-mix(in srgb,var(--bm-accent,#2563EB) 15%,transparent),transparent);pointer-events:none}
.bm-hero-inner{max-width:1200px;margin:0 auto;padding:0 1.5rem;display:grid;grid-template-columns:1fr 400px;gap:3rem;align-items:start}

/* Hero Left */
.bm-badge-row{display:flex;flex-wrap:wrap;gap:.5rem;margin-bottom:1.25rem}
.bm-cat-pill{background:color-mix(in srgb,var(--bm-accent,#2563EB) 20%,transparent);border:1px solid color-mix(in srgb,var(--bm-accent,#2563EB) 40%,transparent);color:#CBD5E1;font-size:.75rem;font-weight:600;padding:.25rem .75rem;border-radius:100px;letter-spacing:.04em;text-transform:uppercase}
.bm-badge{background:rgba(255,255,255,.08);border:1px solid rgba(255,255,255,.15);color:#94A3B8;font-size:.75rem;padding:.25rem .75rem;border-radius:100px}
.bm-h1{color:#fff;font-size:clamp(1.75rem,4vw,2.75rem);font-weight:700;line-height:1.15;margin:0 0 .75rem;display:flex;align-items:center;gap:.75rem}
.bm-h1-icon{font-size:clamp(1.5rem,3vw,2.25rem);line-height:1}
.bm-tagline{color:color-mix(in srgb,var(--bm-accent,#2563EB) 70%,#CBD5E1);font-size:1.0625rem;font-weight:500;margin:0 0 .875rem;line-height:1.4}
.bm-hero-sub{color:#94A3B8;font-size:.9375rem;line-height:1.6;margin:0 0 1.75rem;max-width:55ch}

/* Meta strip */
.bm-meta-strip{display:grid;grid-template-columns:repeat(2,1fr);gap:.75rem 1.5rem}
.bm-meta-item{display:flex;flex-direction:column;gap:.125rem}
.bm-meta-label{font-size:.6875rem;text-transform:uppercase;letter-spacing:.06em;color:#475569;font-weight:600}
.bm-meta-val{font-size:.8125rem;color:#CBD5E1;line-height:1.4}

/* Overview card */
.bm-overview-card{background:#fff;border-radius:1rem;padding:1.5rem;box-shadow:0 4px 24px rgba(0,0,0,.25);position:relative;top:.5rem}
.bm-ov-header{display:flex;align-items:center;gap:.5rem;font-size:.8125rem;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:#2563EB;margin-bottom:.875rem}
.bm-ov-header svg{width:1rem;height:1rem;color:#2563EB;flex-shrink:0}
.bm-ov-text{font-size:.875rem;color:#374151;line-height:1.65;margin:0 0 1rem}
.bm-ov-norm{background:#F8FAFC;border:1px solid #E2E8F0;border-radius:.5rem;padding:.75rem 1rem;margin-bottom:1rem}
.bm-ov-norm-label{display:block;font-size:.6875rem;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:#64748B;margin-bottom:.25rem}
.bm-ov-norm-val{font-size:.8125rem;color:#1E293B;font-weight:500;line-height:1.5}
.bm-ov-reviewer{display:flex;align-items:center;gap:.75rem;padding-top:.875rem;border-top:1px solid #E2E8F0}
.bm-ov-reviewer img{width:32px;height:32px;border-radius:50%;object-fit:cover;flex-shrink:0}
.bm-ov-reviewer>div{flex:1;min-width:0}
.bm-rev-name{display:block;font-size:.75rem;color:#374151;font-weight:500}
.bm-rev-cred{display:block;font-size:.6875rem;color:#64748B}
.bm-read-time{font-size:.6875rem;color:#64748B;white-space:nowrap}

/* ── SECTIONS ────────────────────────────────────────────── */
.bm-sec{padding:4rem 0}
.bm-alt{background:#F8FAFC}
.bm-sec-inner{max-width:1200px;margin:0 auto;padding:0 1.5rem}
.bm-sh2{font-size:clamp(1.25rem,2.5vw,1.625rem);font-weight:700;color:#0F172A;margin:0 0 .5rem}
.bm-slead{color:#64748B;font-size:.9375rem;line-height:1.6;margin:0 0 2rem;max-width:60ch}

/* ── REFERENCE RANGES ─────────────────────────────────────── */
.bm-ranges-list{display:flex;flex-direction:column;gap:.625rem;margin-bottom:1rem}
.bm-range-row{background:var(--rr-bg,#F8FAFC);border:1.5px solid var(--rr-bd,#E2E8F0);border-left:4px solid var(--rr-col,#64748B);border-radius:.625rem;padding:.875rem 1.25rem;display:grid;grid-template-columns:200px 1fr;align-items:center;gap:1rem}
.bm-range-val{font-size:1rem;font-weight:700;color:var(--rr-col,#374151);line-height:1.2}
.bm-range-unit{font-size:.75rem;font-weight:400;color:#64748B}
.bm-range-desc{font-size:.875rem;color:#374151;line-height:1.5}
.bm-ranges-note{font-size:.8125rem;color:#64748B;border-left:3px solid #E2E8F0;padding-left:.875rem;line-height:1.5}

/* ── WHAT RAISES / LOWERS ────────────────────────────────── */
.bm-twocol{display:grid;grid-template-columns:1fr 1fr;gap:3rem}
.bm-col-h2{font-size:1.0625rem;font-weight:700;color:#0F172A;margin:0 0 1.25rem;display:flex;align-items:center;gap:.5rem}
.bm-col-h2 svg{width:1.125rem;height:1.125rem;flex-shrink:0}
.bm-raises-h{color:#DC2626}
.bm-raises-h svg{color:#DC2626}
.bm-lowers-h{color:#059669}
.bm-lowers-h svg{color:#059669}
.bm-factor-list{display:flex;flex-direction:column;gap:.875rem}
.bm-factor{display:flex;gap:.875rem;padding:.875rem 1rem;background:#fff;border-radius:.625rem;border:1px solid #E2E8F0;transition:box-shadow .15s}
.bm-factor:hover{box-shadow:0 4px 12px rgba(0,0,0,.07)}
.bm-factor--up{border-left:3px solid #FCA5A5}
.bm-factor--down{border-left:3px solid #6EE7B7}
.bm-factor-icon{font-size:1.375rem;line-height:1;flex-shrink:0;margin-top:.125rem}
.bm-factor-name{display:block;font-size:.875rem;font-weight:600;color:#1E293B;margin-bottom:.25rem}
.bm-factor-detail{font-size:.8125rem;color:#64748B;line-height:1.55;margin:0}

/* ── CONDITIONS ──────────────────────────────────────────── */
.bm-conditions-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(280px,1fr));gap:1rem}
.bm-condition-card{background:#fff;border:1px solid #E2E8F0;border-radius:.75rem;padding:1.25rem;transition:box-shadow .15s}
.bm-condition-card:hover{box-shadow:0 4px 16px rgba(0,0,0,.08)}
.bm-cond-top{display:flex;align-items:center;gap:.625rem;margin-bottom:.75rem;flex-wrap:wrap}
.bm-cond-dir{font-size:1.25rem;font-weight:700;color:#64748B;line-height:1}
.bm-cond-name{font-size:.9375rem;font-weight:700;color:#0F172A;flex:1;min-width:0}
.bm-urg-badge{font-size:.6875rem;font-weight:700;padding:.2rem .6rem;border-radius:100px;text-transform:uppercase;letter-spacing:.04em;white-space:nowrap}
.bm-urg--emergency{background:#FEE2E2;color:#991B1B}
.bm-urg--urgent{background:#FFEDD5;color:#9A3412}
.bm-urg--watch{background:#FEF9C3;color:#713F12}
.bm-urg--monitor{background:#EDE9FE;color:#4C1D95}
.bm-cond-sig{font-size:.8125rem;color:#475569;line-height:1.55;margin:0}

/* ── PANELS LIST ─────────────────────────────────────────── */
.bm-panels-list{display:flex;flex-direction:column;gap:.875rem}
.bm-panel-row{display:flex;gap:1rem;align-items:flex-start;padding:1.125rem 1.25rem;background:#fff;border:1px solid #E2E8F0;border-radius:.75rem}
.bm-panel-icon{width:2.25rem;height:2.25rem;background:#EFF6FF;border-radius:.5rem;display:flex;align-items:center;justify-content:center;flex-shrink:0}
.bm-panel-icon svg{width:1.125rem;height:1.125rem;color:#2563EB}
.bm-panel-name{display:block;font-size:.9375rem;font-weight:600;color:#0F172A;margin-bottom:.25rem}
.bm-panel-note{font-size:.8125rem;color:#64748B;line-height:1.5;margin:0}

/* ── SCIENCE SECTION ─────────────────────────────────────── */
.bm-science-sec{background:linear-gradient(135deg,#0F172A,#1E293B)}
.bm-science-sec .bm-sh2{color:#fff}
.bm-science-sec .bm-slead{color:#94A3B8}
.bm-sci-header{display:flex;align-items:center;gap:.875rem;margin-bottom:.5rem}
.bm-sci-header svg{width:1.5rem;height:1.5rem;color:#60A5FA;flex-shrink:0}
.bm-sci-lead{font-size:.9375rem;color:#94A3B8;line-height:1.7;margin:0 0 2.5rem;max-width:80ch;border-left:3px solid #2563EB;padding-left:1.125rem}
.bm-sci-facts{display:grid;grid-template-columns:repeat(3,1fr);gap:1.5rem}
.bm-sci-card{background:rgba(255,255,255,.04);border:1px solid rgba(255,255,255,.08);border-radius:1rem;padding:1.75rem;transition:background .2s}
.bm-sci-card:hover{background:rgba(255,255,255,.07)}
.bm-sci-num{font-size:2rem;font-weight:800;color:#60A5FA;line-height:1;margin-bottom:.75rem}
.bm-sci-title{font-size:.9375rem;font-weight:700;color:#E2E8F0;margin:0 0 .75rem;line-height:1.3}
.bm-sci-body{font-size:.8125rem;color:#94A3B8;line-height:1.65;margin:0}

/* ── CLINICAL USE ─────────────────────────────────────────── */
.bm-clinical-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(260px,1fr));gap:1.25rem}
.bm-clinical-card{background:#fff;border:1px solid #E2E8F0;border-radius:.75rem;padding:1.375rem;transition:box-shadow .15s,transform .15s}
.bm-clinical-card:hover{box-shadow:0 6px 20px rgba(0,0,0,.08);transform:translateY(-2px)}
.bm-clinical-icon{font-size:1.75rem;display:block;margin-bottom:.875rem}
.bm-clinical-scenario{font-size:.9375rem;font-weight:700;color:#0F172A;margin:0 0 .5rem;line-height:1.3}
.bm-clinical-detail{font-size:.8125rem;color:#475569;line-height:1.6;margin:0}

/* ── RELATED BIOMARKERS ──────────────────────────────────── */
.bm-related-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(240px,1fr));gap:1rem;margin-bottom:1.5rem}
.bm-related-card{display:block;background:#fff;border:1px solid #E2E8F0;border-radius:.75rem;padding:1.125rem 1.25rem;text-decoration:none;transition:border-color .15s,box-shadow .15s;position:relative}
.bm-related-card:hover{border-color:#2563EB;box-shadow:0 4px 16px rgba(37,99,235,.1)}
.bm-rel-name{display:block;font-size:.9375rem;font-weight:700;color:#0F172A;margin-bottom:.375rem}
.bm-rel-rel{font-size:.8125rem;color:#64748B;line-height:1.5;margin:0}
.bm-rel-arrow{position:absolute;top:1.125rem;right:1.125rem;font-size:1rem;color:#2563EB;opacity:0;transition:opacity .15s,transform .15s;transform:translateX(-4px)}
.bm-related-card:hover .bm-rel-arrow{opacity:1;transform:translateX(0)}
.bm-related-viewall{text-align:center;padding-top:.5rem}
.bm-viewall-btn{display:inline-flex;align-items:center;gap:.5rem;padding:.75rem 1.75rem;background:#0F172A;color:#fff;border-radius:.5rem;font-size:.9rem;font-weight:600;text-decoration:none;transition:background .15s}
.bm-viewall-btn:hover{background:#1E293B}

/* ── RESPONSIVE ──────────────────────────────────────────── */
@media (max-width:900px){
  .bm-hero-inner{grid-template-columns:1fr;gap:2rem}
  .bm-overview-card{top:0}
  .bm-twocol{grid-template-columns:1fr}
  .bm-sci-facts{grid-template-columns:1fr}
  .bm-range-row{grid-template-columns:1fr;gap:.375rem}
}
@media (max-width:640px){
  .bm-hero{padding:2.5rem 0 2rem}
  .bm-sec{padding:2.5rem 0}
  .bm-conditions-grid{grid-template-columns:1fr}
  .bm-clinical-grid{grid-template-columns:1fr}
  .bm-meta-strip{grid-template-columns:1fr}
}