Free Clinical Calculator

ANC Calculator

Absolute Neutrophil Count · CTCAE v5.0 neutropenia grading · Infection risk · Chemo hold thresholds

Enter CBC Differential

WBC (Total White Blood Cell Count)

×10³/µL

Normal: 4.5–11.0 ×10³/µL

Neutrophils (Segs)

Segmented neutrophils from differential

Band Neutrophils (optional)

Include bands for most accurate ANC. Normal: 0–10%.

Clinical Context

General / Community On Chemotherapy / Post-Chemo Bone Marrow Transplant / Stem Cell

Is the patient febrile? (T ≥ 38.3°C / 101°F once, or ≥ 38.0°C / 100.4°F sustained)

CTCAE v5.0 Neutropenia Grading

Grade	ANC	Severity	Typical Action
Normal	≥ 2.0 ×10³/µL	Normal range	No restrictions. Proceed with planned therapy.
Grade 1	1.5–1.99	Mild neutropenia	Monitor closely. Most chemo protocols proceed with caution.
Grade 2	1.0–1.49	Moderate neutropenia	Many protocols hold or dose-reduce. Infection precautions.
Grade 3	0.5–0.99	Severe neutropenia	Hold chemotherapy. Consider G-CSF. Avoid live vaccines.
Grade 4	< 0.5	Agranulocytosis / Life-threatening	Hospitalise if febrile. Broad-spectrum antibiotics. G-CSF. Protective isolation.

Febrile Neutropenia: ANC < 0.5 (or expected to fall < 0.5) + fever ≥ 38.3°C. A medical emergency requiring immediate broad-spectrum IV antibiotics (piperacillin-tazobactam or cefepime) within 60 minutes of presentation.
Formula: ANC = WBC × (% Neutrophils + % Bands) ÷ 100 · Source: CTCAE v5.0 (NCI 2017); IDSA Febrile Neutropenia Guidelines 2010.