Free Clinical Calculator
Kidney Failure Risk Estimator
KFRE 4-variable equation · 2-year & 5-year risk · Evidence-based CKD progression tool
Enter Patient Values
years
mL/min/1.73m²
KFRE applies to CKD stages G3a–G5 (eGFR < 60). Not validated for eGFR ≥ 60.
mg/g
Normal: < 30 mg/g. Microalbuminuria: 30–299. Macroalbuminuria: ≥ 300.
KFRE Risk Tiers
| 5-Year Risk | Tier | Typical Action |
|---|---|---|
| < 5% | Low | Monitor with primary care; recheck labs in 6–12 months |
| 5–19.9% | Moderate | Nephrology referral recommended; aggressive risk factor control |
| 20–39.9% | High | Nephrology follow-up essential; discuss RRT planning |
| ≥ 40% | Very High | Timely RRT education, access planning (fistula/PD); transplant workup |
Source: Tangri N, et al. JAMA 2011;305(15):1553-1559. Validated in 31 cohorts across 30 countries (Tangri et al., JAMA 2016). 4-variable model uses: age, sex, eGFR, UACR.